Cel This proposal focuses on a human disease: epilepsy of the temporal lobe. This syndrome has a relatively stereotyped history. Focal seizures emerge, with a delay of several years in the human, after an initial insult that results in neuronal death. We will use physiology, imaging, anatomy and transcriptomic techniques to ask how an epileptic brain emerges, to define different neuronal cell types in the basal epileptic state and to examine factors associated with the paroxysmal transition to a seizure. Specifically we will ask whether a loss of cholesterol homeostasis is involved in the initial sclerotic neuronal death. We will ask whether proteoglycans deposited in the extracellular space as a generalised wound healing response force the establishment of aberrant synaptic contacts and so facilitate the slow process of epileptogenesis. We will then study the basal state of an epileptic brain. We will establish the physiology, anatomy, connectivity and transcriptome of functionally distinct neurons defined by different contributions to epileptiform activities in human epileptic brain slices. Finally we will seek to establish what sudden changes in field potential, ionic homeostasis, cellular firing and synaptic interactions are associated with the paroxysmal moment of transition to seizure. Dziedzina nauki medical and health sciencesbasic medicineneurologyepilepsymedical and health sciencesbasic medicineanatomy and morphologyhumanitieshistory and archaeologyhistorymedical and health sciencesbasic medicinephysiologyhomeostasis Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-LS5 - ERC Advanced Grant - Neurosciences and neural disorders Zaproszenie do składania wniosków ERC-2012-ADG_20120314 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE Wkład UE € 1 985 057,00 Adres BOULEVARD DE L'HOPITAL 47 75013 Paris Francja Zobacz na mapie Region Ile-de-France Ile-de-France Paris Rodzaj działalności Research Organisations Kierownik naukowy Richard Miles (Dr.) Kontakt administracyjny Alexandra Auffret (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE Francja Wkład UE € 1 985 057,00 Adres BOULEVARD DE L'HOPITAL 47 75013 Paris Zobacz na mapie Region Ile-de-France Ile-de-France Paris Rodzaj działalności Research Organisations Kierownik naukowy Richard Miles (Dr.) Kontakt administracyjny Alexandra Auffret (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
