Objectif In recent breakthrough publications, the effect of fluctuations on the affinity of membrane-confined molecules has been evaluated, and a quantitative model for the time evolution of small adhesion domains has been developed under my leadership. Now I propose to bring my research to a new level by tackling the problem of active and passive organisation of proteins into macromolecular structures on fluctuating fluid membranes, using a physicist’s approach across established disciplinary boundaries.The formation and transport of supramolecular complexes in membranes is ubiquitous to nearly all functions of biological cells. Today, there is a variety of experiments suggesting that macromolecular complexes act as scaffolds for free proteins, overall yielding obstructed diffusion, counterbalanced by active transport by molecular motors. However, an integrative view connecting complexation and transport is largely missing. Furthermore, the effects of membrane mediated interactions and (non)-thermal fluctuations were so far overlooked. Gaining a quantitative insight into these processes is key to understanding the fundamental functioning of cells.Together with my carefully selected team, I will address these intrinsically biological problems, by means of theoretical physics. Phenomena such as active and anomalous transport, as well as complexation are also currently subject to intense research in the statistical and soft matter physics communities. In this context, the aim of this proposal is to bridge the divide between the two worlds and significantly contribute to both physics and the life sciences by developing general principles that can be applied to processes in cells. Resolving these issues is of fundamental importance since it would identify how interactions on the cell surface arise, and may translate directly into pharmaceutical applications. Champ scientifique natural sciencesphysical sciencescondensed matter physicssoft matter physicsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesphysical sciencestheoretical physics Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-PE3 - ERC Starting Grant - Condensed matter physics Appel à propositions ERC-2013-StG Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Coordinateur FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG Contribution de l’UE € 975 040,00 Adresse Schlossplatz 4 91054 Erlangen Allemagne Voir sur la carte Région Bayern Mittelfranken Erlangen, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Ulrike Hoffmann (Mrs.) Chercheur principal Ana-Sunčana Barišić Smith (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG Allemagne Contribution de l’UE € 975 040,00 Adresse Schlossplatz 4 91054 Erlangen Voir sur la carte Région Bayern Mittelfranken Erlangen, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Ulrike Hoffmann (Mrs.) Chercheur principal Ana-Sunčana Barišić Smith (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée RUDER BOSKOVIC INSTITUTE Croatie Contribution de l’UE € 524 960,00 Adresse Bijenicka cesta 54 10000 Zagreb Voir sur la carte Région Hrvatska Grad Zagreb Grad Zagreb Type d’activité Research Organisations Contact administratif Marijana Klasnic-Kozar (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée