Objective "Against the backdrop of an ever-expanding world population and increasingly limited resources, progress in chemistry, and organic chemistry in particular, is essential for the future of humanity. In the last century, transition metal chemistry has completely changed the field of synthesis. Nevertheless, it is often based on rare and toxic metals. Traditional organic chemistry, on the other hand, makes use of cheap and innocuous organic molecules but at the cost of more limited reactivity. Herein, we propose to design new hypervalent iodine reagents, which will combine the high reactivity of metals with the lower toxicity and cost of main group elements while opening new horizons for the synthesis of organic molecules.The most important impact of the project will be to accelerate the innovative circle of progress, especially for research in medicinal chemistry. An extremely useful toolbox, an ""iKit"", will become available for medicinal chemists. The optimal outcome would be a ""magic iodine bullet"", which the chemist can use to install a chemical functional group on an organic molecule of his or her choice.An added impact of the project will be greater understanding of the reactivity of hypervalent iodine reagents and their interplay with metal catalysts, leading to unforeseen applications. This understanding can lead to the development of reactions catalytic in iodine, which can be useful not only for research, but also for the larger scale production of chemicals.Based on the successful outcome of this project, an unlimited number of organic transformations will be possible in the future. Applications will not be solely limited to synthetic chemistry, as there exists the possibility for emergent development of other well-defined reagents tailored to meet the needs of scientists in chemical biology and materials science." Fields of science natural scienceschemical sciencesorganic chemistrymedical and health sciencesbasic medicinemedicinal chemistrynatural scienceschemical sciencesinorganic chemistryhalogensnatural scienceschemical sciencescatalysis Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis Call for proposal ERC-2013-StG See other projects for this call Funding Scheme ERC-SG - ERC Starting Grant Host institution ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE EU contribution € 1 500 000,00 Address BATIMENT CE 3316 STATION 1 1015 Lausanne Switzerland See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Vandevyver (Dr.) Principal investigator Jérôme Waser (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 1 500 000,00 Address BATIMENT CE 3316 STATION 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Vandevyver (Dr.) Principal investigator Jérôme Waser (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data