Objectif The field of phylogenetics is undergoing an important change over recent time. For a long time phylogenetics focussed on describing the species tree as accurate as possible. More recently there is a shift towards a functional inference of the evolutionary process itself, i.e. researchers attempt to infer what processes are most likely responsible for the particular pattern of branching observed in a given phylogeny.Phylogenetics has traditionally been developed for macroevolution. Recently, it has been recognized that the phylogenetic concept is also crucial for improving our understanding of epidemiological processes. In an epidemiological phylogeny, tips of the tree are corresponding to infected hosts (instead of extant species), and branching events correspond to transmission events (instead of speciation events).In the first part of the project, I propose to develop novel phylogenetic methodology that will allow us to characterize fundamental evolutionary processes based on species phylogenies. I will aim at identifying key factors (such as environment, competition between species, or microevolutionary processes) determining macroevolutionary dynamics. Insight into these dynamics will allow us to address fundamental evolutionary questions such as the advantages of recombination as well as to revisit current debates about the impact of climate change on diversity.In the second part of the proposed project, I will develop tools identifying the main drivers responsible for the spread of an epidemic, which may help informing public health intervention strategies. Furthermore, I aim at characterizing bottlenecks at transmission, which may become important for early treatment strategies or vaccine design.Completion of the projects will deepen our understanding of macroevolutionary and epidemiological dynamics, as well as lead to novel phylogenetic tools allowing us to analyse the growing amount of available data, such as next-generation sequence data. Champ scientifique medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesbiological morphologycomparative morphologynatural sciencesbiological sciencesevolutionary biologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesearth and related environmental sciencesatmospheric sciencesclimatologyclimatic changes Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-LS8 - ERC Starting Grant - Evolutionary, population and environmental biology Appel à propositions ERC-2013-StG Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Contribution de l’UE € 1 471 582,00 Adresse Raemistrasse 101 8092 Zuerich Suisse Voir sur la carte Région Schweiz/Suisse/Svizzera Zürich Zürich Type d’activité Higher or Secondary Education Establishments Chercheur principal Tanja Stadler (Dr.) Contact administratif Tanja Stadler (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Suisse Contribution de l’UE € 1 471 582,00 Adresse Raemistrasse 101 8092 Zuerich Voir sur la carte Région Schweiz/Suisse/Svizzera Zürich Zürich Type d’activité Higher or Secondary Education Establishments Chercheur principal Tanja Stadler (Dr.) Contact administratif Tanja Stadler (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée