Objective
How a cell responds to developmental or environmental changes by altering gene expression is a fundamental question in biology. One
critical level of regulation is transcription initiation, which is controlled by large multiprotein complexes, including coactivators. Many studies
have shown that coactivators have distinct activities that play crucial roles in transcription, and their perturbation can cause cancer or
neurodegeneration. Little is known, however, about how these activities integrate external signals to control transcription. I have
established one such coactivator, the highly conserved SAGA complex, as an excellent model to address this question. First, I discovered
that, in the fission yeast Schizosaccharomyces pombe, SAGA regulates the switch from proliferation to differentiation. SAGA uses distinct
activities to function either as a repressor or as an activator of differentiation genes, depending on the levels of extracellular nutrients.
Second, I discovered that S. pombe provides a unique opportunity to study the function of the largest SAGA subunit, Tra1. Its mammalian
homolog, TRRAP, is a key regulator of early embryogenesis and oncogenesis. My overall objective is to address key issues in the
regulation of gene expression by focusing on SAGA, using a combination of genetic, genomic, biochemical, and proteomic approaches.
One goal of this proposal is to identify which nutrient-sensing signaling pathway causes SAGA to switch from a repressor to an activator at
the promoters of differentiation genes. A second objective is to address the role of Tra1 in coordinating the activity of kinases sensing
various cellular stresses and the regulatory roles of transcriptional coactivators. Overall, these studies will illuminate previously unknown
mechanisms for the control of transcription by signal transduction pathways in eukaryotes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences developmental biology
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.