Objective
Nanomedicine and Nanosafety rely on the same fundamental interactions between the nanoparticle interface and the biological milieu surrounding it, and it is this “corona” of proteins and other biomolecules that form at the bio-nanointerface that determines the fate and behaviour of nanomaterials. Understanding, classifying and predicting nanoparticle coronas from their physicochemical properties offers a novel approach to screening for toxicity at early stages of product development and for regulatory purposes.
This biomolecule corona also explains why many nanoparticle targeting strategies, that seem promising when tested under non-physiological conditions, fail when tested in vivo, where multiple competitive interactions occur, and where non-specific binding in many cases blocks the targeting functionality of the nanoparticles, rendering them inactive.
However, despite the rapid increase of our understanding of the issues, methods by which to characterise the functioning bio-nanointerface in biologically relevant environments remain a challenge, and are time consuming and expensive. The partners in the NanoClassifier IAPP project are at the forefront of their respective areas and are pioneering new methodologies for study of complex questions in biologically relevant milieu and represent an optimal partnership to address this challenge.
Together, NUID UCD and Attana AB will develop a cost effective, high throughput screening platform for characterisation of the bionanointerface and its cell-binding partners, to address a range of important questions currently hampering the implementation of nanotechnologies, both in medicine and generally in consumer products. The inter-sectoral nature of the project is critical to its success, as Attana AB bring their platform for kinetic characterization of protein interactions on intact cells in real time, and NUID UCD bring extensive understanding of the bionanointerface and its practical and regulatory significance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences medical biotechnology nanomedicine
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IAPP
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP)
Coordinator
4 DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.