Cel The sensory mechanisms that allow birds to perceive the direction of the Earth’s magnetic field for the purpose of navigation are only now beginning to be understood. One of the two leading hypotheses is founded on magnetically sensitive photochemical reactions in the retina. It is thought that transient photo-induced radical pairs in cryptochrome, a blue-light photoreceptor protein, act as the primary magnetic sensor. Experimental and theoretical support for this mechanism has been accumulating over the last few years, qualifying chemical magnetoreception for a place in the emerging field of Quantum Biology.In this proposal, we aim to determine the detailed principles of efficient chemical sensing of weak magnetic fields, to elucidate the biophysics of animal compass magnetoreception, and to explore the possibilities of magnetic sensing technologies inspired by the coherent dynamics of entangled electron spins in cryptochrome-based radical pairs.We will:(a) Establish the fundamental structural, kinetic, dynamic and magnetic properties that allow efficient chemical sensing of Earth-strength magnetic fields in cryptochromes.(b) Devise new, sensitive forms of optical spectroscopy for this purpose.(c) Design, construct and iteratively refine non-natural proteins (maquettes) as versatile model systems for testing and optimising molecular magnetoreceptors.(d) Characterise the spin dynamics and magnetic sensitivity of maquette magnetoreceptors using specialised magnetic resonance and optical spectroscopic techniques.(e) Develop efficient and accurate methods for simulating the coherent spin dynamics of realistic radical pairs in order to interpret experimental data, guide the implementation of new experiments, test concepts of magnetoreceptor function, and guide the design of efficient sensors.(f) Explore the feasibility of electronically addressable, organic semiconductor sensors inspired by radical pair magnetoreception. Dziedzina nauki natural scienceschemical sciencesphysical chemistryphotochemistrynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesphysical scienceselectromagnetism and electronicsspintronicsengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsnatural sciencesphysical scienceselectromagnetism and electronicssemiconductivity Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-PE4 - ERC Advanced Grant - Physical and Analytical Chemical sciences Zaproszenie do składania wniosków ERC-2013-ADG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Wkład UE € 2 654 296,00 Adres WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Zjednoczone Królestwo Zobacz na mapie Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Peter John Hore (Prof.) Kontakt administracyjny Gill Wells (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Zjednoczone Królestwo Wkład UE € 2 654 296,00 Adres WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Zobacz na mapie Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Peter John Hore (Prof.) Kontakt administracyjny Gill Wells (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP Stany Zjednoczone Wkład UE € 342 766,00 Adres 3451 WALNUT STREET ROOM P 221 19104 Philadelphia Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Elizabeth Peloso (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych