Objective
Inflammatory sites contain a number of different cell types that contribute to the swelling and the destruction of surrounding tissue. In rheumatoid arthritis this inflammation occurs at joints. The cells implicated in coordinating and amplifying this damage are CD4 T cells. Much is known about the mediators responsible for attracting CD4 T cells into inflammatory sites. However, the signals responsible for retaining these cells are only poorly characterised. Understanding which key signals control the retention of CD4 T cells could lead to novel treatment strategies that force CD4 T cells to leave inflammatory sites and thereby reduce inflammation.
Reducing the numbers of CD4 T cells at inflammatory sites may not be sufficient to reduce inflammation. It will be important, therefore, to specifically tolerise the CD4 T cells that perpetuate the inflammatory response. I have found that the induction of tolerance in previously activated or memory CD4 T cells located in secondary lymphoid organs is possible. However, whether it is possible to induce tolerance in CD4 T cells located in inflammatory milieus at peripheral site is unknown.
This project will use novel, cutting edge in vivo mouse models to examine CD4 T cells and the immune cells which they interact with at inflammatory sites. By manipulating the cells and signals present in inflammatory sites and determining the effect this has on CD4 T cells, the project will examine the signals that contribute to the retention of the CD4 T cells. In addition, these studies will examine whether tolerance can be induced in CD4 T cells located at inflammatory sites. This will provide critical information about whether improvements in chronic inflammation are only possible following treatments that reduce CD4 T cell retention to inflammatory sites and simultaneously induce tolerance. These studies will provide an innovative framework for alternative therapeutic targets that alleviate chronic inflammation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences basic medicine immunology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
G12 8QQ Glasgow
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.