Objective
"Treatment of eye diseases is severely hindered by the tear fluid and eye lid movement removing the drug. As a consequence, very frequent administration of highly concentrated eye drops is necessary, causing substantial side effects. These side effects occur very often and can range from simple irritations to life threatening anaphylactic shocks in extreme cases. The other shortcoming in treating eye-related diseases is poor compliance, due to frequent dosing.
We have developed a drug carrier system for eye drops that have high affinity to the cornea. This allows for a drastically lower concentration of the active compound and less frequent administration. A lower regime results in a better compliance, a higher effectiveness of the drug and less side effects. These nanoparticles can be combined with a wide variety of ophthalmic drugs, including the ones that have been abandoned due to severe side effects. Our approach has been proven during preclinical studies in rat models and even human tissue using two nanoparticle-antibiotic combinations that have shown exceptionally long lasting survival times on the eye of up to four hours.
In this project we would like to complete our set of preclinical data regarding efficacy, scope and toxicity of the carrier to achieve commercialization of the drug delivery system."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- medical and health sciences clinical medicine ophthalmology
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2013-PoC
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
9712CP Groningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.