Obiettivo 1) STUDY OF MOLECULAR INTERACTIONS OF ENVIRONMENTAL MUTAGENS AND CARCINOGENS AT DNA LEVEL. 2) DEVELOPMENT AND VALIDATION OF METHODS TO IDENTIFY NON-GENOTOXIC CARCINOGENS. 1) THE WORK IS INTENDED TO CONTRIBUTE TO THE DETERMINATION, AT AN INDIVIDUAL LEVEL, OF THE DNA ADDUCTS ATTRIBUABLE TO ALKYLATING CARCINOGENS E.G. NITROSAMINES. IN ADDITION, AN ATTEMPT IS MADE TO ASSESS THE BIOLOGICAL SIGNIFICANCE OF SUCH DNA CHANGES IN RELATION TO CANCER INDUCTION. IN PARTICULAR, DNA MODIFICATIONS ATTRIBUABLE TO CARCINOGEN EXPOSURE WILL BE EXAMINED IN VARIOUS BANKS OF HUMAN TISSUES. 2) THE INHIBITION OF JUNCTIONAL INTERCELLULAR COMMUNICATION IS USED AS AN END-POINT TO DETECT THE TUMOUR PROMOTING ACTIVITY OF ENVIRONMENTAL CHEMICALS. FOR THIS PURPOSE A "DYE TRANSFER" ASSAY IS TO BE DEVELOPED AS A SHORT-TERM TEST FOR PROMOTING AGENTS. CELLS DERIVED FROM DIFFERENT TISSUES ARE USED TO OVERCOME PROBLEMS OF TISSUE SPECIFICITY. Campo scientifico natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineoncologynatural sciencesearth and related environmental sciencesenvironmental sciencespollution Programma(i) FP1-ENVPROT 4C - Multiannual research and development programmes (EEC) in the field of the environment - Protection of the environment -, 1986-1990 Argomento(i) Data not available Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore INTERNATIONAL AGENCY FOR RESEARCH ON CANCER Contributo UE Nessun dato Indirizzo Cours Albert-Thomas 150 LYON Francia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato