Objectif IN ORDER TO UNDERSTAND THE RADIOBIOLOGICAL RESPONSE OF EUKARYOTIC CELLS IT IS NECESSARY TO STUDY THE INDUCTION OF THE CRITICAL MOLECULAR DAMAGE BY IONIZING RADIATION AND ITS REPAIR/MISREPAIR. THE OBJECTS OF STUDY WILL INCLUDE YEAST CELLS AS WELL AS HUMAN AND OTHER MAMMALIAN CELL LINES. EVIDENCE, DERIVED FROM SEVERAL SOURCES INCLUDING OUR OWN LABORATORIES IMPLICATES THE DNA DOUBLE-STRAND BREAKS (DSB) IN BOTH CHROMOSOME ABERRATION INDUCTION AND CELL KILLING AFTER EXPOSURE TO IONIZING RADIATION. THE INVESTIGATIONS WILL BE EXTENDED TO INHERITABLE GENETIC CHANGES (POINT MUTATIONS) IN HAPLOID YEAST CELLS. Work is concerned with monoenergetic low energy electron irradiation of yeast and mammalian cells to study the induction of cell killing and aberrations, mutations and deoxyribonucleic acid (DNA) double strand breaks as a function of electron energy.MONOENERGETIC LOW ENERGY ELECTRON IRRADIATION OF YEAST AND MAMMALIAN CELLS TO STUDY THE INDUCTION OF CELL KILLING, ABERRATIONS, MUTATIONS AND DNA DOUBLE STRAND BREAKS AS A FUNCTION OF ELECTRON ENERGY. Champ scientifique natural sciencesbiological sciencesgeneticsDNAnatural sciencesphysical sciencesnuclear physicsnatural sciencesbiological sciencesgeneticsmutationnatural sciencesbiological sciencesgeneticschromosomes Programme(s) FP1-RADPROT 6C - Multiannual research and training programme (Euratom) in the field of radiation protection, 1985-1989 Thème(s) Data not available Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur GSF - FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT GMBH Contribution de l’UE Aucune donnée Adresse Ingolstaedter Landstrasse 1 85764 NEUHERBERG Allemagne Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
