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SPONTANEOUS AND RADIATION-INDUCED CHROMOSOME MUTATION AND DELETIONS OF SPECIFIC CHROMOSOME REGIONS OF THE HUMAN KARYOTYPE WHICH CONTAIN GENES OF KNOWN CLINICAL IMPORTANCE

Cel


The aim of the project was to examine the distribution, type and consequences of spontaneous and radiation induced deletions in the human chromosome complement with emphasis on the short arm of chromosome 11. Chromosome 11 was selected since it was known to contain a number of genes involved in carcinogenesis (eg Wilms' tumour, H-ras 1,T cell acute leukaemia) and to sustain a larger number of deletions than expected on chromosome length following exposure to ionising radiation. Constitutional deletions of the short arm of chromosome 11 were consistent with viability when hetrozygous and various sizes of deletions were available in the human population which were associated with specific disease states (eg Wilms' tumour, aniridia etc).
SPONTANEOUS AND RADIATION-INDUCED CHROMOSOME MUTATION AND DELETIONS OF SPECIFIC CHROMOSOME REGIONS OF THE HUMAN KARYOTYPE WHICH CONTAIN GENES OF KNOWN CLINICAL IMPORTANCE.

Temat(-y)

Data not available

Zaproszenie do składania wniosków

Data not available

System finansowania

CSC - Cost-sharing contracts

Koordynator

Medical Research Council (MRC)
Wkład UE
Brak danych
Adres
20 Park Crescent
W1N 4AL London
Zjednoczone Królestwo

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Koszt całkowity
Brak danych