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FERMENTOR MODELLING FOR AUTOMATION AND OPTIMAL PROCESS CONTROL

Ziel

BETTER UNDERSTANDING OF REACTOR DYNAMICS. INCREASE IN THE CURRENT PRODUCTIVITIES OF THE PRODUCTION OF ANTIBIOTICS AND FOR VITAMINS BY 10 - 20 %.
Pharmaceutical industries use fermentation processes for the production of several base products. This type of process is controlled by traditional monitoring mechanisms which maintain the fermentation processes within predetermined operating ranges and thus prevent the occurrence of large scale failures. However, operating factors are not kept at reaction optima since control does not take into account the kinetics of the various growth conditions.
Products, such as enzymes, interferons or human insulin, produced by special strains of the bacterium Escherichia coli: maximum oxygen input has to be guaranteed and the substrate concentration (carbon source) has to be held in a narrow range. Due to the lack of sensors, the substrate and biomass concentrations cannot be measured directly. Therefore, they must be estimated mathematically. A model for the E coli process was developed, implemented in a computer system and verified. It was possible to calculate accurate estimates of the entire process status during fermentation. Thus, the process could be optimally controlled increasing the productivity as compared to conventional techniques by a factor of 2. Also, an experimental laboratory bioreactor was designed, built and tested. It was possible with such a bioreactor to reach a cell concentration higher than that in a conventional one, when oxygen was supplied with air.
THE SCOPE OF THE PROPOSED PROGRAM IS THE DEVELOPMENT OF A MATHEMATICAL MODEL TAKING INTO ACCOUNT OPERATING PARAMETERS AND BIOCHEMICAL KINETICS AND THE APPLICATION OF SAME TO IMPROVE THE OPERATION OF BATCH FERMENTATION PROCESSES.

THE INTENTION IS TO USE THIS MODEL IN INDUSTRIAL OPERATION FOR AN OPTIMUM CONTROL OF FERMENTATION PROCESSES, BY MEANS OF PROGRAMMABLE MICRO-PROCESSORS AND/OR MICRO-COMPUTERS.

SOCIETE BERTIN WILL STUDY THE APPLICATION TO PRACTICAL PROCESS AND THE AUTOMATION.

THE INDUSTRIAL TESTING OF THE MODELLING WILL BE PERFORMED ON ONE OF THE CURRENT PRODUCTION : ANTIBIOTICS AND/OR VITAMINS.

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Bertin & Cie
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59 rue Pierre Curie Zone Industrielle des Gatines
78373 Plaisir
Frankreich

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