Objective Pituitary tumours are an important and relatively common clinical problem, but very little is known about their pathogenesis. An important potential site of abnormal cellular function is at the level of regulated gene expression. We propose to compare adenoma with normal hypophysis using a multidisciplinary approach : standardised morphological charaterization, insitu hybridization purification of pituitary cell populations, 2 gel analysis of cytoplasmic and nuclear proteins and protein-DNA interactions by gel retardation and DNA footprinting. This information should be of great help in improving an understanding of the pathogenic mechanisms which operate in human pituitary tumours. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator VRIJE UNIVERSITEIT BRUSSEL EU contribution No data Address Pleinlaan 2 1050 BRUXELLES Belgium See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all ARISTOTLE UNIVERSITY OF THESSALONIKI Greece EU contribution No data Address University Campus, Egnatia Street, Administration 54006 THESSALONIKI See on map Total cost No data UNIVERSITE CLAUDE BERNARD LYON 1 France EU contribution No data Address Boulevard du 11 Novembre 1918, 43 69622 VILLEURBANNE See on map Total cost No data UNIVERSITE DE LIEGE*ULG Belgium EU contribution No data Address PLACE DU 20 AOUT 7 4000 LIEGE See on map Total cost No data UNIVERSITY OF MANCHESTER United Kingdom EU contribution No data Address Oxford Road M13 9PL MANCHESTER See on map Total cost No data Universidade do Porto Portugal EU contribution No data Address S/N,Rua Dr. Roberto Frias 4200 Porto See on map Total cost No data
