Objective
RNA silencing has become a major focus of molecular research around the world with important implications in biotechnology and medicine. RNA silencing involves processing of dsRNA by the enzyme Dicer, into small RNAs, 21-to-25 nucleotides in length. One of the two RNA strands is then incorporated into a protein complex called RISC (RNA induced silencing complex) that invariably contains a member of the highly conserved ARGONAUTE protein family. The incorporated small RNA then guides the complex to silence partly or fully complementary RNA. RNA silencing is important for the regulation of development in animals and plants, but plays also an antiviral role in plants and invertebrates (including worms and flies). In light of the apparent importance of RNA silencing in most eukaryotes, it is surprising that molecular mechanisms regulating ARGONAUTE proteins (and RISC) turnover have received so little attention. For instance, it is unknown whether ARGONAUTE proteins remain very stable when incorporated in RISC and how many times they can operate on different mRNA targets while loaded with the same siRNA/miRNA. More importantly, intriguing questions concern ARGONAUTE protein turnover under stress conditions. For instance, it is unknown whether ARGONAUTE proteins (and RISC) are degraded during stress, a situation where siRNA/miRNA populations quickly change and RISC re-programming is expected. My research project aims to answer to these questions. The content of this program is multidisciplinary combining molecular and cell biology, genetics, biochemistry and structural biology. Based on its approaches and already pioneering data recently obtained in my lab, I believe that this ERC research project has the potential to go substantially beyond the current state of the art in this field by providing deep insights into the regulatory mechanisms that control and mediate ARGONAUTE proteins turnover, in particular during stress responses.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics nucleotides
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences biological sciences molecular biology structural biology
- natural sciences biological sciences zoology invertebrate zoology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2013-ADG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.