Objective So far, there are no effective treatments for neuropathic pain (NP), and current treatments suffer from serious unwanted side effects.The NGF ligand-receptor system has recently emerged as a novel target for NP of great therapeutic potential, a master regulator, controlling both neuropathic and inflammatory components. Besides being a multi-component system, it also modulates the endocannabinoid (EC) signalling. Blocking the NGF signaling system is therefore a rational and thoroughly validated approach to pain therapy. Extensive evidence for potent analgesic efficacy of antiNGF mAbs has been obtained in preclinical models and in clinical trials,showing remarkable analgesic efficacy and creating great expectations for this new class of analgesic compounds.However potential safety concerns related to off-target side effects have been raised and recently the FDA called for more preclinical research. To fully exploit the huge therapeutic potential of NGF system, we built a consortium of leading researchers in the NGF, EC and pain scientific arena.The innovative proposal will investigate new strategies for the treatment of different NP forms, based on the NGF system and its interplay with EC signalling, focussing at different levels of the pain transmission and perception systems.The project results will provide solid, mechanism-based grounds for the development of already identified second-generation therapeutics, based on the “NGF target” system, as well as for the identification and validation of new druggable targets emerging from the elucidated mechanisms. It will also identify biomarkers for NP, validated in animal models and clinical samples, that could result in future clinical benefits, for the stratification of patients suffering from different neuropathies and their treatment.The project will contribute to the understanding and controlling NP mechanisms, with an interdisciplinary approach, leading to the development of next-generation NGF targeting drugs. Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.2.2.1-5 - Understanding and controlling pain Call for proposal FP7-HEALTH-2013-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator SCUOLA NORMALE SUPERIORE EU contribution € 1 159 329,00 Address PIAZZA DEI CAVALIERI 7 56126 Pisa Italy See on map Region Centro (IT) Toscana Pisa Activity type Higher or Secondary Education Establishments Administrative Contact Larissa Zoni (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all FONDAZIONE EUROPEAN BRAIN RESEARCHINSTITUTE RITA LEVI Italy EU contribution € 837 898,00 Address VIA REGINA ELENA 295 00161 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Silvia Marinelli (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AARHUS UNIVERSITET Denmark EU contribution € 776 000,00 Address NORDRE RINGGADE 1 8000 Aarhus C See on map Region Danmark Midtjylland Østjylland Activity type Higher or Secondary Education Establishments Administrative Contact Lone Romar Larsen (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE UNIVERSITAET WIEN Austria EU contribution € 710 215,00 Address SPITALGASSE 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Jürgen Sandkühler (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LEVICEPT LTD United Kingdom EU contribution € 271 334,00 Address RAMSGATE ROAD DISCOVERY PARK INNOVATION HOUSE CT13 9ND SANDWICH KENT See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Simon Westbrook (Dr.) Links Contact the organisation Opens in new window Total cost No data KING'S COLLEGE LONDON United Kingdom EU contribution € 610 214,00 Address STRAND WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDAD DE SALAMANCA Spain EU contribution € 492 314,00 Address CALLE PATIO DE ESCUELAS 1 37008 Salamanca See on map Region Centro (ES) Castilla y León Salamanca Activity type Higher or Secondary Education Establishments Administrative Contact María De Los ángeles Serrano García (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GENOMNIA SRL Italy EU contribution € 505 143,00 Address CORSO MAGENTA 56 20123 MILANO See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anna Moles (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 498 384,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Jérémy Bonnassies (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data