Objective
"The deadliest form of human malaria is caused by the protozoan parasite, Plasmodium falciparum, which annually infects millions worldwide. Its virulence is attributed to its ability to evade the human immune system, by modifying the host red blood cell surface to adhere to the vascular endothelium and to undergo antigenic variation. Antigenic variation is achieved through switches in expression of hypervariable surface ligands named PfEMP1. These proteins are encoded by a multi-copy gene family called var. Each individual parasite expresses a single var gene at a time, whereas the remaining ~60 var genes found in its genome are maintained in a transcriptionally silent state, a phenomenon known as ""allelic exclusion"". These antigenic switches allow the parasite to avoid the human immune response and maintain a long-term infection. How mutually exclusive expression is regulated is still elusive.
The rationale of the proposed study is that understanding the molecular mechanisms by which the parasite evade human immune attack would lead to the development of therapeutic approaches that disrupt this ability and would give the human immune system an opportunity to clear the infection and overcome the disease.
I will focus this research project on understanding one of the unsolved mysteries in gene expression which is responsible for regulating antigenic variation in P. falciparum: the nature of ""communication"" between genes that allows expression of only a single gene at a time and the selection of the ""chosen one"" for activation while the rest of the gene family remains silent.
The expected outcome of this knowledge is new concepts for disrupting the parasite’s ability to evade immune attack which will be exploited for the discovery of novel targets for drug and vaccine development. In addition, it will unravel mechanisms of allelic exclusion that extend beyond malaria virulence into fundamental aspect of gene expression in other organisms."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2013-CoG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
91904 JERUSALEM
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.