Objective
The main objective is the development of highly multiplexed affinity proteomics tools for point of care diagnostics. Enabled by the world's largest resource of antibodies to human protein targets generated within the framework of the Human Protein Atlas program, the aim of this application is to develop new concepts in translational medical research to allow dramatic improvement in performance and accessibility of point of care tests in both high and low resource clinical settings in infectious diseases, autoimmune conditions and several cancers. To achieve the goal, developments will be made in 1) detection principles and sample preparation, 2) rapid and low cost protein microarrays assays and 3) novel amplification strategies. Strategies will be developed to for the first time enable highly multiplexed sandwich detection across the analytical range of the plasma proteome. Four different novel microarray formats amenable for point of care are presented that each will allow dramatically improved multiplexity and high performance. Different types of new multifunctional silica/gold nanoparticles exhibiting combinations of magnetic, fluorescent, electro-active, enzymatic and optical qualities that will allow deterministic actuation and multimodal detection options will be synthesized and applied for exquisite sensitivity and rapid detection. Following the technology development, developed assay systems will be implemented for full plasma proteome analysis and in the three clinical areas: infectious diseases, autoimmune conditions and cancers. Collaborations with clinical researchers in all the relevant fields have already been established. In theses clinical fields, a body of previous research efforts has shown that highly multiplexed plasma analysis may dramatically improve diagnostic accuracy, and it is here that the novel comprehensive point of care systems presented in this proposal may conceivably create the largest impact for patients and health care systems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences health sciences infectious diseases
- medical and health sciences clinical medicine oncology
- engineering and technology nanotechnology nano-materials
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2013-CoG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
100 44 Stockholm
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.