Objective
When materials are implanted into the body they initiate an inflammatory response that is difficult to control. Consequently medical implants are tolerated by the body rather than fully integrated; the material is often sealed off from the body in a fibrotic capsule. Most recent research suggests that morphology is a decisive immunomodulatory trigger and may favor a healing-like reaction of the innate immune system, especially of macrophages.
I have pioneered a single-step method to generate non-woven fibrous scaffolds with surface chemistry control that allows specific cell adhesion. Additionally, my laboratory recently established melt electrospinning writing (MEW) that allows automated scaffold production by solvent-free electrostatic drawing with precise morphology control through rational deposition of polymer filaments in micrometer resolution.
Design2Heal is based on this world-wide unique combination of technologies and proposes to combine form (scaffold morphology) with function (surface chemistry) to generate biomaterials that are designed to heal and improve implant integration. Pioneering and ground breaking research within Design2Heal includes:
• A single-step procedure to fabricate MEW scaffolds with controlled surface functionalities for specific bioactivation.
• Unraveling the immunomodulatory potential of generic scaffold parameters (diameter, morphology) and surface functionalization (peptides, sugars, glycosaminoglycans) for rationally designed scaffolds in vitro with primary human innate immune cells.
• Resolve the immunomodulatory effects of cellular cross-talk and interaction between human immune cells, mesenchymal stem cells and endothelial progenitor cells in defined geometric confinements.
• In vivo proof-of-principle in the murine model
In case of success, Design2Heal will be a ground breaking first step towards actively healing implants independently of the affected tissue, with tremendous impact on healthcare worldwide.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences cell biology
- medical and health sciences basic medicine immunology
- medical and health sciences medical biotechnology cells technologies stem cells
- engineering and technology industrial biotechnology biomaterials
- medical and health sciences medical biotechnology implants
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2013-CoG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
97080 Wurzburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.