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Content archived on 2024-05-28

ZF-Delivery

Objective

Within our ERC Starting Grant “Direct Drug Delivery”, we developed a method controlled fusion of liposomes and cells: a new pathway for direct drug delivery.

Our method of membrane fusion is inspired by natural occurring SNARE proteins, which control this process in-vivo. A set of complementary peptide amphiphiles were designed and these are able to induce the rapid and efficient fusion between two opposing membranes. In the ERC-project we have shown that our method of fusion can be applied to liposomes and to live cells. Since liposomes can be loaded with drugs, this enables the direct delivery of drugs into live cells.

We have recently found that our method also works in-vivo, which makes surface tagging and fusion applicable to zebrafish larvae. Drug screening and testing in Zebrafish larvae is becoming increasingly more popular as it reduces cost and enables rapid screening, making it easier to find new drugs. In this proposal, we want to investigate whether the market for applying our tagging and fusion of liposomes with zebrafish larvae enabling rapid in vivo drug screening is sufficiently large to make the commercialization of this method attractive for investors.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

ERC-2013-PoC
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

CSA-SA(POC) - Supporting action (Proof of Concept)

Host institution

UNIVERSITEIT LEIDEN
EU contribution
€ 131 926,00
Address
RAPENBURG 70
2311 EZ Leiden
Netherlands

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Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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Beneficiaries (1)

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