Objective
Every year in the European Union, an estimated 25000 patients die because of a serious resistant bacterial infection acquired in hospital. The bacterium Staphylococcus aureus is a main opportunistic pathogen responsible for food poisoning, skin infections and nosocomial infections. In the recent years, small ribonucleic acids (sRNAs) have attracted great interests as ubiquitous regulators. Some of them have been directly related to commitment of virulence of this species. However, a serious bottleneck in unraveling their biological roles is due to the difficulty in identifying targets of the RNome (any non-conventional RNA with regulatory functions). There is a strong and urgent need to propose and use novel technologies for target detections of the bacterial RNomes. SarHyb intends to identify the primary molecular targets of staphylococcal RNome with a multidisciplinary approach. Therefore, t will combine the use of novel bacterial genetic hybrid systems, molecular biology and biochemistry. The researcher has an in depth expertise in the use or large-scale studies and yeast as a surrogate system which he used during his postdoctoral training at Yale University (USA). The main objective of SarHyb is to provide a list of prioritized sRNA candidates to target for the development of novel drug therapy directed against this pathogen. The transfer of knowledge from the researcher will consolidate the position of the host institution as a leader in Europe and worldwide in the use of hybrid-systems.
Major Scientific findings expected during the course of the project include the development of the first bacterial hybrid systems devoted to RNA-target identification, an exhaustive list of mRNA and proteins directly regulated by sRNAs, and an in-depth understanding of the molecular signals allowing S. aureus to adapt to its environment. If successful, this ambitious research project will impact both basic and translational research at the European Union level.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
35065 RENNES CEDEX
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.