Objective
Intravital microscopy (IVM) methods are enjoying an ever broader acceptance as they can be used to gain insight into cell biology in vivo. Unfortunately, most set-ups use window chambers (e.g. cancer) or isolated organs, all highly artificial model systems which are often not compatible with survival imaging. Because of these caveats, imaging in orthotopic locations is always preferable and can theoretically be achieved via motion compensation and tissue stabilization techniques. Recently, different approaches have been proposed including the use of suctioning devices for lung imaging. Unfortunately these approaches are not very effective in achieving stabilization. Moreover many of them induce severe damage to the myocardium. In this proposal we intend to develop a in-vivo real-time intravital microscopy imaging system for imaging moving organs (specifically the beating heart) at the sub-cellular resolution level, capable of compensating all motion artifacts inevitably present in in-vivo models. Our approach will use a combination of rigid motion stabilization through the design of novel stabilizers and sophisticated algorithms for acquisition during advanced cardiopulmonary gating. This system will allow for the first time to study in vivo the biology and physiology in the beating heart. This is at present a totally unexplored field due to the current lack of availability of any imaging technique. Results will be potentially exciting and innovative and will open a new paradigm in the understanding of the physiological properties of the heart and immune system responses.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- natural sciences physical sciences optics microscopy
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
37129 Verona
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.