Obiettivo "Chronic inflammation is central to disease progression and organ failure in the majority of common human diseases, including cardiovascular disease, inflammatory bowel disease, chronic kidney & liver disease, gout, asthma, arthritis and cancer. Together, these chronic conditions contribute substantially to morbidity and mortality and generate a profound socioeconomic burden. The NLRP-STRUCTURE project will pave the way for the development of first-in-class drugs that can target select NLRP inflammasome members within different diseases endemic to the EU population. World-leading protein expression technologies will be integrated with unique chemoproteomic drug discovery platforms with the purpose of achieving rationalized drug development. Structure-activity guided medicinal chemistry will allow the team to propose drug leads that can be used in the synthesis of a new generation of small molecule pharmaceuticals for chronic inflammatory disease management. The project can provide data and information sourced from health databases, basic and translational research, and in-house analysis by a network of academic/clinical/industry experts. Thus, NLRP-STRUCTURE has the potential to develop new diagnostic, prognostic and therapeutic strategies that will improve the clinical care of patients across a wide range of chronic and debilitating disease. The entry of pipeline molecules will boost the anti-inflammatory therapeutics industry, thereby bringing about further economic stimulation to the therapeutics market in the coming years. The research objectives of NLRP-STRUCTURE will position the Host and partners in positions as world leader, as an acknowledged centre of global excellence in NLRP therapeutic discovery. Integral to the proposal is the development of patent landscapes and strategic partnerships that will play substantial roles in shaping the market in the future." Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencesinflammatory diseasesmedical and health sciencesbasic medicinemedicinal chemistrymedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesclinical medicinehepatology Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2013-IIF - Marie Curie Action: "International Incoming Fellowships" Invito a presentare proposte FP7-PEOPLE-2013-IIF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IIF - International Incoming Fellowships (IIF) Coordinatore ASTON UNIVERSITY Contributo UE € 154 617,60 Indirizzo ASTON TRIANGLE B4 7ET Birmingham Regno Unito Mostra sulla mappa Regione West Midlands (England) West Midlands Birmingham Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Roslyn Bill (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato