Objective
"Cell migration is the core of myriad of phenomena in health and disease. Physical forces exerted during collective cellular motion trigger structural adaptations and signaling events that are of paramount importance in tissue engineering, stem cell differentiation and cancer. A spectacular example of coordinated movements towards a useful endpoint is vasculogenesis, the formation ""de novo"" of a network of vessels and capillaries from dispersed endothelial cells. In tissue engineering, precise control of the process of vasculogenesis is essential to create 3D tissue constructs with a proper nutrient and oxygen availability. Such control will only be possible with a deep understanding of cell-cell and cell-matrix mechanical interactions, and biochemical guidance of migrating cells during early 3D vasculogenesis. Providing a theoretical model, experimentally validated, of such multicellular self-organization would highly help in modulating the final architecture of the vascular network. In this project microfluidic experiments are proposed to engineer vasculogenesis within 3D gel matrices, mimicking the native cell environment. The expertise of the outgoing host on microfluidics will ensure the experimental control of chemical and mechanical factors coupled with image acquisition. A continuum-discrete multiscale model, tuned to reproduce mechano-chemical guidance of collectives of cells will be developed in parallel. Measurements of cell-matrix tractions in 3D will be performed at the European host for further mechanical characterization. Traction measurements will be coupled with microfluidics to provide in vitro observations at a high spatiotemporal resolution and extensively validate the in silico model. While advancing the control of 3D vasculogenesis, the project will generate precious knowledge and innovative methodologies that will benefit European research on stem cell mechanobiology during tissue regeneration and in the future, cancer research."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08028 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.