Development of a Sustainable Route to the Important Platform Chemical 3-Hydroxypropanoic Acid Using Synthetic Biology and a Geobacillus Chassis

Projektinformationen

GEO-HPA

ID Finanzhilfevereinbarung: 625585

Abgeschlossenes Projekt

Startdatum 1 Januar 2015

Enddatum 31 Dezember 2016

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 309 235,20

EU-Beitrag € 309 235,20

Koordiniert durch

THE UNIVERSITY OF NOTTINGHAM
United Kingdom

Ziel

The environmental damage caused by the indiscriminate use of fossil fuels for chemical manufacture threatens the very future of our planet. Attention must now focus on biological routes that convert lignocellulosic biomass (LCB) into the required platform chemicals. 3-hydroxypropanoic acid (3-HP) has been ranked as the third most important chemical that can be derived from LCB by the US Department of Energy. However no commercial biological process is presently available. Current attempts are thwarted by the high cost of feedstock, low titers and yield and 3-HP toxicity.

The goal of GEO-HPA is the development of a bioprocess for 3-HP production from LCB using the bacterium Geobacillus (the process organism of the UK biofuel company TMO Renewables Ltd). Geobacillus is capable of growth at high temperatures (up to 70 C), can rapidly metabolize a wide range of substrates (including pentose sugars and insoluble substrates) typically found in LCB hydrolysates and is thus capable of the simultaneous saccharification and fermentation of this feedstock. The pathways necessary production will be introduced into the Geobacillus genome using Synthetic Biology approaches, coupled with the deliberate inactivation of genes encoding competing pathways. Culture conditions, process variables and reactor operation mode will be optimized. The in situ removal of 3-HP and process scale-up will lead to improved 3-HP titers, yield and productivity.

The project will capitalize on the extensive expertise of Dr Kumar and the unique range of ‘state-of-the-art’ tools, resources and partners (TMO Renewables Ltd) available at the host institution. It will lead to complementary exchange of capabilities and knowledge between Europe and India, and the establishment of a long lasting collaboration. The outcome will be an economic and sustainable commercial route to 3-HP that will enhance EU competitiveness in the development of bio-based production of chemicals from renewable sources.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › microbiology › bacteriology
• natural sciences › biological sciences › synthetic biology
• natural sciences › physical sciences › astronomy › planetary sciences › planets
• natural sciences › biological sciences › genetics › genomes
• engineering and technology › industrial biotechnology › biomaterials › biofuels

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2013-IIF - Marie Curie Action: "International Incoming Fellowships"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2013-IIF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IIF - International Incoming Fellowships (IIF)

Koordinator

THE UNIVERSITY OF NOTTINGHAM

Kontakt Verwaltung

Paul Cartledge (Mr.)

• EU-Beitrag: € 309 235,20
• Adresse: University Park ; NG7 2RD Nottingham ; Vereinigtes Königreich
• Region: East Midlands (England) › Derbyshire and Nottinghamshire › Nottingham
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten