Objective
Prostate cancer can be stratified as ETS gene rearranged (ETSR) and
non-rearranged (ETSNR), with the latter comprising a heterogeneous
group of 50-60% of all cancers. This project will characterize a subgroup
of ETSNR cancers that have a CHD1 deletion (CHD1del). Recent
sequencing studies have elucidated CHD1- cancers as ETSNR, and
commonly PTEN and p53 wildtype and SPOP mutated, comprising up to
26% of all prostate cancers (1). ETSR cancers largely have hormone
driven oncogenes that may have prognostic and predictive utility (2, 3).
Less is known about ETSNRCHD1del cancers. Their lack of ETS fusions
raises concern that these may not be generated through androgen
receptor (AR) transcription and are not AR driven. ETSNRCHD1del cancers
have a huge excess of somatic intrachromosomal rearrangements (up to
800) compared to ETSR cancers presumably due to a DNA repair defect
(1). This is supported by CHD1’s association with the SSRP1, part of the
FACT complex, that is implicated in transcriptional regulation and DNA
repair (4-9). We hypothesize that CHD1 deleted tumors are less
sensitive to endocrine and taxane therapy, have a worse prognosis
and need alternative treatment strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine oncology prostate cancer
- natural sciences biological sciences genetics DNA
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IIF
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 3RP London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.