SYSBIODREZProject reference: 626190
Funded under :
SYSTEMS BIOLOGY APPROACH TO PREDICTING OUTCOMES OF LUNG CANCER THERAPIES AND STRATEGIES TO OVERCOME DRUG RESISTANCE IN VITRO
Total cost:EUR 269 743,8
EU contribution:EUR 269 743,8
Call for proposal:FP7-PEOPLE-2013-IIFSee other projects for this call
Funding scheme:MC-IIF - International Incoming Fellowships (IIF)
There has been extensive research dedicated to identifying predictive biomarkers of tumor sensitivity to ligand-based therapies. Although some biomarkers have emerged, there is still no comprehensive understanding that unifies the observed tumor cell type-specific behaviors, in particular the differential responses to anti-cancer drugs.
The collective realization is that no single protein measurement is predictive of therapeutic outcome. Large-scale studies focusing on multiple genetic biomarkers may be partially inadequate given the observed fractional killing of genetically-identical clonal cell populations.
The objective of this proposal is to address this deficiency by coupling high-content analyses (dynamic live cell imaging, high-throughput assays) with theoretical and computational methods to provide a global understanding of the origins of tumor cell heterogeneity in response to anti-cancer drugs that target the apoptotic signaling pathway at the receptor level. Ultimately this approach will serve to identify, on a tumor cell type basis, the most predictive set of biomarkers and design optimal therapeutic combinations.
EU contribution: EUR 269 743,8
RUE MICHEL ANGE 3
Tel.: +33 4 93954260
Fax: +33 4 92960339