Objective
Many important protein families such as signaling receptors, ion channels, structural proteins and enzymes are embedded in the membrane of cells. Despite their importance, understanding of their structure, dynamics and interactions lacks behind that of soluble proteins due to their hydrophobic nature which makes them difficult to study experimentally. We propose to recruit and retain in the Division of Metabolic and Vascular Health at the University of Warwick, Judith Klein-Seetharaman, membrane protein expert from the University of Pittsburgh, USA. In an interdisciplinary approach combining computational and experimental studies, she looks at these proteins from both, structural and systems biology point of views. She proposes to study membrane protein folding by characterizing denatured states of the model system and G protein coupled receptor mammalian rhodopsin in molecular detail by predicting these states and experimentally validating them with biophysical approaches such as 19F NMR spectroscopy. She will extend these studies to mutant rhodopsins that cause the retinal degeneration disease Retinitis pigmentosa and that are known to misfold and to other membrane proteins, in particular carnitine palmitoyltransferase 1A, of particular interest to our division. She will also investigate interactions of proteins with lipids using coarse grained simulations and in a systems biology approach interactions with other proteins to define the human membrane receptor interactome by establishing new collaborations within the division and with the Chemistry department. In this approach, computational machine learning methods are used to integrate large –omics databases to predict what interactions are likely for any given membrane receptor and then test the predictions using surface plasmon resonance and the TOXCAT assay. She proposes to disseminate her results in lecture series, conferences, a website, journal publications and through implementation of a graduate course.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
- natural sciences biological sciences biochemistry biomolecules proteins protein folding
- natural sciences computer and information sciences artificial intelligence machine learning
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CV4 8UW COVENTRY
United Kingdom
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