Objective
Synthetic molecules that mimic the structure of the part of a folded protein involved in recognition events (protein epitope mimetics, PEMs) can access biological targets previously deemed as “undruggable” and are considered as a potential source of future therapeutics. So far, PEMs could effectively mimic only individual secondary structure elements of peptides and proteins. The major goal of this project is the development of a novel versatile platform for the design of multifaceted 3D architectures as PEMs of higher order structure elements and discontinuous epitopes of bioactive protein surfaces. The platform is based on cyclic pseudopeptide scaffolds comprising triazole rings linked by conventional amide bonds that are designed to allow for precise topological positioning of biomolecules. The synthetic strategy relies on sequential assembly on solid support of tailor-made building blocks through cycles of alternated amide coupling and Copper(I)-catalyzed azide-alkyne cycloaddition reactions. The building blocks will be prepared in solution and using solid phase synthesis (SPS) to produce macromolecular units bearing bioactive peptide segments. Conclusively, these PEM systems can provide further insight into protein folding mechanism and recognition processes of bioactive protein surfaces. On the other side, improving pharmacodynamic and pharmacokinetic properties of natural peptides and proteins, a number of biomedical applications can be targeted. Specific focus will be devoted to the development of PEM anti-infective agents and the mimicry of structural and functional properties of trimeric HR1 complex of the HIV-1 protein gp41. Moreover, the developed platform can allow for the design of chimeric PEM systems that present saccharide and peptide units in a convergent manner as in the surface of native glycoproteins. This “discontinuous epitope” approach will be applied to improve pharmacological properties of the antimicrobial PEM systems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20126 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.