Objective
This proposal aims to integrate the fields of synthetic biology and synthetic organic chemistry. This project aims to achieve this through the application of biocompatible chemistry: non-enzymatic reactions capable of modifying small molecules in the presence of a living system. The idea of using microbial metabolites as reagents for non-enzymatic transformations in the presence of the producing organism will greatly expand the range of organic molecules that can be accessed using natural and engineered living systems.
We plan on applying a newly discovered engineered strain of E.coli that produces molecular hydrogen to important synthetic targets. We have demonstrated the use of this microbe in the presence of a palladium catalyst to hydrogenate a range of alkene- and alkyne-containing unnatural substrates. We propose to use this biocompatible hydrogenation reaction to the synthesis of industrially important advanced biofuels from biologically available starting materials. This would avoid the current need to extract the products of an engineered organism for further chemical manipulations, and would be the first example of the synthesis of these proposed molecules through purely biological means. Using bacterial olefin biosynthesis for the production of alkanes by interfacing single-/multi-system bacterial metabolism and a non-enzymatic, biocompatible hydrogenation reaction will represent an important advance in metabolic engineering and in biofuel manufacture.
We then plan to develop a batch- or flow-reactor set-up in order to investigate the viability of advanced biofuel synthesis using an engineered microbe/non-enzymatic chemistry synthesis systems for the bulk production of these important target molecules.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry
- natural sciences biological sciences synthetic biology
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences catalysis
- engineering and technology industrial biotechnology biomaterials biofuels
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.