Objective
"Reliable chromosome segregation during cell division is absolutely critical for the survival, health and fertility of eukaryotes. In polyploids, the presence of an additional set of identical (or closely related) chromosomes makes correct segregation particularly difficult and as a result most newly formed polyploids form multivalents at metaphase I and have low fertility. By contrast, natural polyploid populations have usually evolved a highly stable meiosis with strict bivalent formation and high fertility. Recently, ASY1 was confirmed as playing an important role in this “diploidisation” of meiosis in autotetraploid Arabidopsis arenosa. ASY1 is one of several meiotic genes, mainly involved in chromosome synapsis and cohesion, that show signatures of strong selection in tetraploid A. arenosa and has also been implicated in the diploidisation of meiosis in polyploid wheat. The work outlined in this proposal will interrogate our working hypothesis that the tetraploid ASY1 variant promotes meiotic adaption in autotetraploid A. arenosa through a reduction in cross-over frequency, perhaps mediated through increased cross-over interference strength. The proposed research will also determine whether the tetraploid ASY1 variant promotes similar meiotic behaviour in other Arabidopsis species. This research will underpin an understanding of chromosome pairing and segregation that is still lacking in polyploids, and is relevant to a wide range of fields from crop improvement to cancer biology."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography fertility
- medical and health sciences clinical medicine oncology
- agricultural sciences agriculture, forestry, and fisheries agriculture
- natural sciences biological sciences genetics heredity
- natural sciences biological sciences genetics chromosomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75007 PARIS CEDEX 07
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.