Objective
Regulated transport of mitochondria is essential for providing ATP spatio-temporaly to power nerve cell function and calcium buffering during release of neurotransmitters or post-synaptic receptor activation. The major player of this transport machinery is Mitochondrial Rho GTPases Miro-1 and Miro-2 present at the mitochondrial outer membrane which controls binding to the Kinesin for transport along microtubules. Miro-1 and 2 are paralogs shares ~60% homology in mammals (while nematode Caenorhabditis elegans and plants have 3 paralogs) while others have only one copy of Miro proteins. Using high resolution 3D live cell imaging, co-immunoprecipitation followed by mass spectrometric identification, expression of genetically encoded sensors in combination with pharmacological, electrical and optogenetic stimulation of neuronal activity in vivo, the molecular mechanism that allow two Miro proteins to tailor the spatial distribution and morphology of mitochondria will be explored. A key goal will be to explore the differential role of the Miro-1 and Miro-2 which can regulate diverse cellular processes such as constitutive and activity-dependent mitochondrial transport, ER-Mitochondria contact and calcium signalling in cultured cells and dendritic shafts and synapses in vivo. I will also try to identify novel proteins that interact with Miro-1 and Miro-2 proteins and their role in maintaining mitochondrial morphology and transport. To extend this knowledge further the role of Miro proteins in axonal transport and calcium signalling in vivo will be investigated with a deletion model in C. elegans. These studies will significantly advance our current understanding of the role played by mitochondrial trafficking for controlling diverse cellular function and may also help understand of how disrupted mitochondrial trafficking and function contribute to diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences biochemistry biomolecules proteins
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- natural sciences biological sciences zoology mammalogy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1E 6BT LONDON
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.