Objective
"This project aims to investigate the role of vitamin D status in survival of patients diagnosed with oesophageal or gastric cancer. The ultimate goal of the project is to help inform cancer treatment and improve survival in these patients.
Both oesophageal and gastric cancer have exceptionally poor prognosis, with a 5-year survival of only 15-20%. Moreover, little improvement in survival has been made in either cancer type. Observational and ecological studies have investigated associations between vitamin D proxies (e.g. vitamin D dietary intake, sunshine hours or UVB irradiance) and upper gastrointestinal cancers. These studies largely show poorer prognosis in cancer patients with lower estimated vitamin D levels. Vitamin D deficiency is prevalent in Europe and the investigation of any potential detrimental effects of vitamin D deficiency is of major significance for the population.
To date, no well-designed study has investigated the relationship between post-diagnostic circulating 25-hydroxyvitamin D (25-OHD, the best indicator of vitamin D status) and prognosis in oesophageal cancer patients. Therefore, the main aim of this proposal is to explore the relationship between 25-OHD concentration at the time of diagnosis and survival in oesophageal cancer patients. We also propose to investigate, for the first time in Caucasians, the relationship between 25-OHD and survival in gastric cancer patients.
Furthermore, we seek to assess the mechanism of these associations, as understanding the biological pathway could add evidence in support of their causality. The principle way that vitamin D exerts its biological action is by binding to the vitamin D receptor (VDR). Therefore, presence of functioning VDR is crucial for its downstream effects, such as expression of E-cadherin (CDH1). To address this, we will assess the expression of the VDR and CDH1 genes in tissue, and we will genotype common polymorphisms in VDR gene that are known to affect its function."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
D02 CX56 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.