Objective
Fungal pathogens cause disease in important cereal and horticultural crop plants dramatically reducing yields and quality. Preventing fungal disease in crop plants would ensure global food security and reduce agricultural inputs with respect to fungicide application. Following the recognition of microbial attack both plants and animals produce a nitric oxide (NO) burst which is directly antimicrobial. However, little is known about the molecular mechanisms underlying how NO inhibits pathogen growth, in particular with regards to fungal pathogens. During plant infection fungal pathogens secrete virulence proteins (effectors) to suppress the immune response and alter host metabolism. There is emerging evidence that NO targets and alters these secreted effectors. NO is able to post-translationally modify proteins by reacting with specific cysteine residues to form an S-nitrosothiol (SNO), subsequently controlling protein activity and function. This project aims to investigate the influence NO has on fungal crop pathogens during attempted infection of the plant host. The mechanisms that these pathogens might use in order to detoxify NO to avoid its antimicrobial effects will be identified and investigated. Pathogen effectors that are S-nitrosylated during infection will be identified and the impact on virulence elucidated. Understanding the role NO has on pathogenic fungi during attempted colonisation of the plant host will allow new broad spectrum resistance strategies to be developed to control these important crop pathogens.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences microbiology mycology
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences nutrition
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds cereals
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
4 DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.