Objective
Hematopoieic stem cells (HSCs) are characterized by their ability to self-renew and differentiate into cells of all hematopoietic lineages. During steady-state, HSCs are mostly quiescent and responsible for normal hematopoietic differentiation. In cases of stress such as infection or injury, HSCs need to be activated and repair the hematopoeitic system in a regenerative response that involves synchronous and hierarchical replacement of the hematopoietic lineages. Multiple signaling pathways constantly specify a complex network of stimuli that HSCs need to decode and act on. Rapid recovery after injury is crucial for patients receiving myeloablative treatments, or suffering from a hematologic malignancy. It is therefore important to understand how signaling pathways control HSC responses during normal hematopoietic differentiation and stress induced regeneration. Our goal is to use zebrafish genetics and genome-wide techniques to understand how signaling pathways synergize and integrate with the internal hematopoietic program and control normal hematopoietic differentiation and stress-induced regeneration. Ultimately our approach may reveal new players of hematopoietic regeneration that can be exploited therapeutically.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- medical and health sciences medical biotechnology cells technologies stem cells
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.