Objective
Regeneration and embryonic development have in common that they result in fully functional tissues and organisms. Some species are able to regrow entire organisms from small fragments, while others are able to regenerate only specific structures, tissues or cell types. What are the molecular underlying regeneration? What is the degree of conservation between regeneration and embryonic development? What are the molecular reasons for differences in regenerative capacities between organisms? Are these differences linked to the embryonic history of each species? How is regeneration triggered in response to internal or external stresses? How are regeneration capacities impaired during aging? Can we increase the regeneration capacities of tissues by re-deploying an early developmental program?
With the enhancement of modern genomics, regeneration biology has become a re-emerging field of interest, allowing to revisit the relationships between regeneration, embryogenesis, stress response, stem cell biology, aging and cancer. Due to the lack of accessibility to embryonic material in the main whole body regeneration models, the question about the molecular relationship between regeneration and early development remains largely unanswered.
An emerging concept that is central to my project is that embryonic developmental processes are re-used during regeneration. Specifically, I propose to functionally reconstruct the gene regulatory networks underlying regeneration in the sea anemone Nematostella vectensis, that possesses all required attributes for the proposed work, using genomics and functional techniques such as morpholino based knockdown approaches in the adult.
The generation of high quality molecular data from a uniquely suitable species will provide basic information about the molecular events underlying regeneration and allow direct comparisons between regeneration, embryogenesis, stress response and aging events within the same animal.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences cell biology
- natural sciences biological sciences developmental biology
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.