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Content archived on 2024-06-18

Dissecting the retinal inputs to behaviorally relevant computations in the central brain

Objective

A key function of the visual system is to extract behaviourally relevant features about the visual scene from the barrage of
incoming photons. This process begins in the retina, a powerful image processer that recent studies have revealed
separates the incoming information into ~20 distinct neural representations. Within central visual brain regions specific
details of the visual scene are often neatly organized, remaining spatially segregated from each other. Despite our detailed
knowledge of how information is organized within the visual system, progress in gaining a mechanistic understanding of
how the brain is able to extract salient features from the visual scene, or how this information is used to guide behavior has
stalled. Too often each brain centre is studied in isolation, meaning the details of its inputs and function of its outputs are
frequently a point of conjecture. In particular, the input to central visual areas, despite the accumulated evidence, are
repeatedly assumed to simply be a relayed representation of the visual scene from the retina.

In order to provide mechanistic insight into how visual information is processed in central brain regions and understand how
it is used to direct behavior this proposal will delineate the inputs, originating in the retina, to specific behavioural
computations in central brain regions. This will allow us to determine which retinal channels are assigned dedicated
computational tasks and how information from the retina is recombined to highlight key aspects of the visual scene used to
direct behavior. To accomplish this conditional expression systems and trans-synaptic viral based circuit tracing will be
combined with targeted patch-clamp recording and calcium imaging to link genetically identified cell types of the retina with
behaviourally relevant computations in central brain regions. This work will provide insight into the circuit mechanisms used
by the brain to process the visual world.

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2013-CIG
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-CIG - Support for training and career development of researcher (CIG)

Coordinator

VIB VZW
EU contribution
€ 100 000,00
Address
SUZANNE TASSIERSTRAAT 1
9052 ZWIJNAARDE - GENT
Belgium

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Research Organisations
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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