Objective
Post-transcriptional regulation (PTR) is increasingly recognized as a pervasive and complex system that regulates every aspect of RNA metabolism including splicing, localization, stability and translation. PTR is mediated by the interactions of trans-factors such as RNA-binding proteins (RBPs) and miRNAs with cis-acting elements located in mRNAs. Regulatory networks controlled by RBPs and miRNAs have been viewed as two distinct mechanisms; however, a number of recent studies have shown that RBPs and miRNAs can act in coordination. Previous studies of PTR have ignored this fact and only focused on a single class of factors, i.e. either RBPs or miRNAs. In this proposal, we will (i) develop computational models that consider the joint effect of multiple RBPs and miRNAs to explain PTR events (ii) integrate our PTR model with additional regulatory elements such as transcription factors, epigenetic marks and copy number changes to explain more general phenomena such as differential gene expression in cancer.
Recent explosion of data in (i) RBP binding specificities, (ii) post-transcriptional fate of mRNAs (e.g. localization, stability)
and (iii) mRNA-bound proteome in human cells have enabled the systematic study of post-transcriptional events, which is
the main goal of this proposal. The proposed project will start with a genome-wide mapping of binding sites of RBPs and
miRNAs in mRNAs. These potential binding sites will then be investigated for cooperative or competitive interactions
between RBPs and miRNAs. Independent binding sites and interactions will be converted to features, and used in statistical
models to identify cis-regulatory elements that are predictive of PTR events such as localization,
stability, and differential gene expression in cancer. Identification of such cis-regulatory elements and their interacting trans factors will lead to new insights in disease-causing perturbations, and hence, will hopefully lead to novel approaches for
their cure.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine oncology
- natural sciences mathematics applied mathematics statistics and probability
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
07230 ANTALYA
Türkiye
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.