Objective
Developing new methods to functionalize molecules controlling their stereochemistry is of outmost important in almost any area of chemistry. However, factors such as costs, efficiency, sustainability and waste production are a major concern. As the pharmaceutical industry is increasingly aware of the importance of and greater clinical success in creating biomolecules with 3-D architectures there is a strong impetus to try to develop new efficient and sustainable asymmetric methods. The impact of organocatalysis (the use of small organic molecules to promote asymmetric transformations) has been immense across many aspect of society spanning from the synthesis of pharmaceutical compounds to agrochemicals and materials. However, whilst useful for the activation of compounds such as aldehydes and ketone, this concept cannot be used for the functionalization of carboxylic acids. This limits the development of new and efficient methods because carboxylic acids frequently represent the starting material as well as the final product of many synthetic sequences. This proposal seeks to explore fundamentally new ideas based around rationally designed boron transformations aimed at the development of novel approaches towards asymmetric, transition metal-free functionalization of carboxylic acids. The proposed approach relies on the activation of carboxylic acids by the addition of chiral boronic acids catalysts to generate chiral mono-acyl boronate intermediates. Subsequent addition of a nucleophile (or a diene) would results in highly valued and polyfunctional non-racemic carboxylic acids, amides and thioesters with water as the stoichiometric waste. Preliminary DFT calculations suggest that the asymmetric induction is viable. This proposal is aimed at the career development of applicant by allowing him to establish an independent research career on a scientific area that is expected to have a big impact on the society.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences organic chemistry aldehydes
- natural sciences chemical sciences organic chemistry organic acids
- natural sciences chemical sciences organic chemistry ketones
- natural sciences chemical sciences catalysis
- natural sciences chemical sciences inorganic chemistry metalloids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
M13 9PL Manchester
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.