Objective
The goal of this research is to use next generation sequencing (NGS) to identify genes that have pronounced, early-onset effects on specific cognitive and psychiatric processes by sequencing children with exceptional cognitive abilities or exceptionally early onset psychotic illness. Mental disorders present an enormous societal burden, largely because of our inability to effectively treat them. An improved understanding of their genetic basis could lead to the identification of novel drug targets and improved treatments. Unfortunately, genetic analysis of common neuropsychiatric disorders such as schizophrenia, bipolar disorder, epilepsy, autism and ADHD suggests that they are very genetically heterogeneous, and very large sample sizes will be needed to gather statistical evidence for individual genes and variants. However, there is also evidence for a considerable genetic overlap between different neuropsychiatric traits, suggesting that identifying key genes underlying any neuropsychiatric or neurocognitive process could potentially benefit the entire class of disorders. My program of work seeks to identify genes underlying both pathological and non-pathological traits that: (i) represent the extreme of a particular neurocognitive domain, and (ii) onset very early in childhood before any known environmental contributors would be expected to have much impact. The underlying hypothesis is that in some cases these traits are caused by a single genetic variant that can be identified by comparing the genomic sequence of the affected and unaffected family members. During the period of reintegration to the UK that is supported by the requested funding (2014-2018), I will focus my research program on childhood onset schizophrenia, and exceptional early-onset mathematical and musical abilities.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology epilepsy
- medical and health sciences clinical medicine psychiatry schizophrenia
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.