Objectif Cardiac electro-mechanical coupling is known to contribute to sudden cardiac death, a significant public health issue, but its role in the intact human heart is undetermined, mainly because of the lack of data. The proposed work will:Record a unique data-set from patients acquired prior to cardiac surgery. The studies include high-density electrical mapping of the ventricles, speckle-tracking echocardiography, ECG and photoplethysmography.We will quantify the relationship between regional strain and the dispersion of repolarization, and develop a non-invasive biomarker of dispersion of repolarization, which incorporates strain heterogeneity and T-wave morphology. We will quantify the contribution of the regional strain on the spatiotemporal organization of repolarization alternans, and determine the effect of changes in the cardiac strain on the ECG-based indices of alternans. Additionally, we will develop an algorithm for the detection of pulse wave alternans in the photoplethysmogram recorded from the finger, and develop a mobile application to detect repolarization alternans from a fingertip pulse wave using the built-in camera lens.We hypothesize that:1) Alterations in the strain of the myocardium have a direct, predictable effect on electrophysiology: changing action potential duration.2) In patients with coronary artery diseases, mechanical heterogeneity contributes to electrical heterogeneity, creating a pro-arrhythmic substrate.3) Changes in cardiac load alter the magnitude and the spatial distribution of beat-to-beat repolarization alternans. Mechanical heterogeneity enhances the degree of regional discordance of alternans and increases the arrhythmic risk.4) The beat-to-beat variability of repolarization is coupled to the variability of contraction, and can be detected in the pulse wave recorded from a fingertip photoplethysmogram.Outputs from this project are expected to have an impact on the understanding and prediction of ventricular arrhythmia Champ scientifique medical and health sciencesclinical medicinecardiologycardiovascular diseasescardiac arrhythmiamedical and health scienceshealth sciencespublic healthmedical and health sciencesclinical medicinesurgeryengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsoptical sensors Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Appel à propositions FP7-PEOPLE-2013-IEF Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur UNIVERSITY COLLEGE LONDON Contribution de l’UE € 221 606,40 Adresse GOWER STREET WC1E 6BT LONDON Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Giles Machell (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
