Objective
This project will establish a computational strategy which exploits polypharmacology to identify drug targets in biological systems implicated in cancer. The value of our polyphamacology platform will be tested by application to glioblastoma multiforme, a deadly brain cancer. The aim will be to identify multiple targets in protein networks linked to glioblastoma to thereby enable repositioning of drugs against that cancer. The novelty of the work will lie in its use of protein domain structure data to link known and putative drug compounds to biological networks.
The project is proposed as an interdisciplinar and intersectoral research: (i) It will be developed on the basis of the domain structure resources and expertise in the host group of Prof. Orengo at University College London (UCL), and the compound-target libraries and drug discovery expertise within the pharmaceutical company GlaxoSmithKline, which will be a seconded host institution; (ii) it will benefit from the expertise in protein-ligand interactions developed in the group of Prof. Janet Thornton and the group of Prof. John Overington at the European Bioinformatics Institute; (iii) the experimental testing of putative drug compounds will be undertaken in collaboration with the group of Dr Matilda Katan-Muller at UCL and the group of Prof David Selwood at UCL.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1E 6BT LONDON
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.