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Content archived on 2024-06-18

Monitoring awareness during anaesthesia – a multi-modal approach

Objective

Modern anesthesia is achieved through the administration of a 'chemical cocktail' of agents, each targeting a specific desirable effect (loss of awareness, analgesia, amnesia and immobility). Given that there are no strict dosages for these combinations of agents, the anesthetist follows a set of approximate dosage guidelines and adjusts these based on patient characteristics and past experience. However, administering an incorrect dosage could have serious complications: over-administration of anesthetics could result in cardiovascular depression, while under-administration in intraoperative awareness. The latter in particular could result to severe psychological consequences for the patient and economic consequences in the form of large insurance claims. Given that an estimated 234.2 million major surgical procedures are conducted annually worldwide, the seemingly small reported incidence of awareness (0.1-0.8%) corresponds to approximately 1,873,600 people. Despite the existence of commercially available devices that monitor anesthetic depth through the patient’s electrical brain activity (EEG), reliability and robustness issues stop them from becoming part of routine surgical practice. The project proposes a new direction in the field: the combination of various multi-modal signals to obtain a holistic view of anesthetic-induced changes. How is the body as a whole affected by this chemical 'cocktail'? What are the measurable effects of anesthesia on the relationships between different signals? The project will investigate such questions through the collection and study of multi-modal signals during surgery, and their applicability for wakefulness/anesthesia discrimination. Training in various research and complementary skills will be achieved through the multi-disciplinary nature of the project. Integration of the fellow in an environment with an impressive track record in cutting-edge biomedical research will provide structured long-term career development.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2013-IEF
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
EU contribution
€ 299 558,40
Address
SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
SW7 2AZ London
United Kingdom

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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