Objective
The proposed research programme will advance the state of the art in nanostructured array preparation. This will be achieved by utilising microcavity arrays generated via standard nanosphere lithographic approaches and reproducibly introducing additional nanostructures via plasmonically directed growth. The resulting arrays will lead to greater optical signal enhancement due to the additional plasmonic coupling and focusing generated by the extra metallic structures. Importantly, these arrays will not only lead to increased plasmonic activity but will be reproducibly prepared, unlike current approaches used to enhance the activity of microcavity arrays.
Nanostructured arrays of this nature can be used to enhance optical signals such as those generated in Raman and fluorescence spectroscopy. Therefore, following their development they will be used in the preparation of a novel drug permeability assay. Biomimetic lipid bilayers, representing natural cell membranes, will be supported on the arrays and the interaction of drug molecules of interest monitored via metal enhanced fluorescence, surface enhanced Raman spectroscopy and electrochemical impedance.
The proposed approach will result in the measurement of a dissociation constant for specific drug-membrane combinations. This dissociation constant will be an improved parameter compared to the currently utilised partition coefficient that is measured for drugs between two immiscible liquids. An improved insight into drug-membrane interactions, such as those provided by the proposed novel drug permeability assay, will have significant impacts in the cosmetics and pharmaceutical fields. Product development will be better informed at a much earlier stage and only the most promising targets advanced to the more expensive in vitro and in vivo testing stages. This will ensure products are successfully brought to market quicker than currently happens and savings are made within the development pipeline.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics spectroscopy emission spectroscopy
- natural sciences biological sciences biochemistry biomolecules lipids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.