Objetivo Evolution is a process that largely occurs within populations. Contrary to common belief, the evolution of complex genome architecture is not driven by natural selection alone. In small populations, genetic drift overwhelms weak selective forces, yielding populations that evolve “in principle” neutrally. Non-adaptive stochastic forces such as mutation, recombination, and genetic drift, also influence genetic material composition under neutrality. On the other hand, selection optimizes expression levels by operating on sequence polymorphisms at gene regulatory regions. Slightly deleterious mutations on the regulatory regions of genes, that affect the binding of transcription factors may increase in frequency by chance alone. Other non-adaptive processes such as gene duplications can change the distribution of the links on each node (gene) of the network.Here, I propose to study the evolution of gene regulatory networks in the population level, by means of genetic drift and natural selection. I will focus on the effects of mutation, recombination, genetic drift and various forms of natural selection (e.g. stabilizing and positive selection) on the polymorphism patterns of the promoter regions. The goal is to identify polymorphism patterns that are created exclusively by natural selection and not by non-adaptive processes. Ámbito científico natural sciencesbiological sciencesgeneticsmutationnatural sciencesbiological sciencesgeneticsgenomes Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Convocatoria de propuestas FP7-PEOPLE-2013-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador IDRYMA TECHNOLOGIAS KAI EREVNAS Aportación de la UE € 168 794,40 Dirección N PLASTIRA STR 100 70013 Irakleio Grecia Ver en el mapa Región Νησιά Αιγαίου Κρήτη Ηράκλειο Tipo de actividad Research Organisations Contacto administrativo Papatheodorou Zinovia (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos