Objective
Most proteins secreted by eukaryotic cells use the endoplasmic reticulum (ER)-to-Golgi pathway of secretion. This is dependent on signal-peptide sequences that ensure protein translocation into the ER and their progress to the cell surface through vesicular flow via the Golgi apparatus. However, a substantial number of proteins that lack a signal-peptide sequence are secreted without entering the classical ER-to-Golgi pathway. Instead they follow the so-called “unconventional pathway of protein secretion”. A well established route within this unconventional pathway refers to cytoplasmic proteins transported to the extracellular environment by autophagosome-like vesicles, such as the Saccharomyces cerevisiae protein Acb1. Secretion of Acb1 in yeast cells is concomitant with the biogenesis of recently characterized membrane structures called CUPS (compartments for unconventional protein secretion) which are thought to function as a sorting platform for Acb1 secretion and possibly for other proteins known to follow similar routes of secretion. The overall aim of this proposal is to further characterize the biogenesis of CUPS in Saccharomyces cerevisiae and to understand their role in the unconventional pathway of secretion, i.e. to address the hypothesis that CUPS are sorting platforms for proteins to be unconventionally secreted. Determining the composition of CUPS, understanding their biogenesis and how their cargo is sorted will surely provide mechanistic insight on how Acb1 and other proteins, which include the inflammatory cytokine IL-1β or Galectin-3 in mammalian cells, are secreted.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08003 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.