Objective
The ability to detect pathogenic cells is essential for many applications in clinical diagnostics. Great attention has been focused on the field during the last decade, stressing the importance of an early and unequivocal detection of certain diseases for a successful diagnosis and thus, a favourable treatment and prognosis. To achieve this, molecular tools are required that unambiguously recognise appropriate cell surface molecules that come along with disease onset and progression. Aptamers are short single-chained oligo(deoxy)nucleotides that interact with cognate target molecules with high affinity and specificity. Within the last years they gained much attention to be employed as cell–recognition tools. In this research proposal, DNA aptamers that reveal broad-spectrum interaction patterns with cancer cells derived from solid tumours will be employed for developing a robust, multiplex assay format likely to determine molecular fingerprints of the most prevalent and lethal cancers worldwide. Furthermore, the multiplex aptamer-based assay will allow gaining information of the relative expression levels of yet unknown marker proteins present on different cancer cells. This will enable profiling of cancer cells, which is highly convenient for diagnostic monitoring. A second goal is the identification of the molecular targets of the employed aptamers. This will be achieved by using siRNA libraries, essentially covering the entire human genome and the knockdown of putative target molecules. Loss of aptamer binding in relation to employed siRNA molecules will lead to information on cognate aptamer target molecules, and they will be studied as possible new biomarkers candidates.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics nucleotides
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
53113 BONN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.