Objective
This proposal seeks to develop a new strategy for chemical synthesis which we term “Assembly Line Synthesis”. Our plan is to develop new reactions and strategies which enable us to essentially grow a carbon chain with complete control over its shape (stereochemistry) and functionality (which groups are incorporated) in a single operation. Our unique methodology involves the reaction between a lithiated carbamate and a boronic ester to give the homologated product. This chemistry can be done in an iterative manner, without the need for purification between steps, enabling complex molecules to be created with complete control of both relative and absolute stereochemistry. To date we have done 7 homologations in one pot with full stereocontrol. Indeed, through choosing the approriate stereochemistry of substituents along a carbon chain, we have grown a molecule which adopts a linear conformation. We are interested in the further development of the homologation of boronic ester methodology and its application in the synthesis of chemically and biologically useful molecules.
We now plan to apply this methodology to the synthesis of the hydroxyl phthioceranic acid, a potent antigen that stimulates the immune response towards tuberculosis. We expect to make this molecule in just 2-3 discrete operations, a far cry from the 30+ steps taken in the past. In collaboration with Prof. Wender at Stanford, we also plan to prepare improved transporters to carry lipophilic drug molecules (like the potent anti-cancer compound taxol) into cells. We will use our iterative methodology to create lipophilic carbon chains bearing polar guanidinium rich side arms with specific shape and improved transporter properties.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine pneumology tuberculosis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BS8 1QU Bristol
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.