Objetivo Standard of care strategies for the treatment of cancer still relies heavily on non-specific radiation- and chemotherapy. They are commonly associated with severe toxicities and in many cases only offer limited benefit for the patient. The targeted delivery of radionuclides, cytotoxic drugs and proinflammatory cytokines into malignant tissue, on the other hand, can markedly improve the therapeutic index and overall efficacy of such substances. Whilst monoclonal antibodies are the most widely used delivery vehicles to date, we believe that small molecule ligands will offer improved targeting properties. Most importantly, depth of tumour penetration and tumour-to-blood distribution ratio after injection should be significantly superior. We therefore propose to systematically investigate the targeting performance of somatostatin receptor non-internalizing ligands for the targeted delivery of cytokines into somatostatin receptor-overexpressing tumours. This project aims at (1) developing a general chemical approach for building safe small molecule cytokine conjugates (SMCC) (2) demonstrate that a somatostatin antagonist, non-internalizing ligand can selectively accumulate in somatostatin receptor-overexpressing cancers and (3) when site-specifically conjugated to proinflammatory interleukin-12, these novel SMCC are highly effective for the treatment of acute myeloid leukaemia (AML). Ámbito científico medical and health sciencesclinical medicineoncologyleukemianatural scienceschemical sciencesnuclear chemistryradiation chemistry Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Convocatoria de propuestas FP7-PEOPLE-2013-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Aportación de la UE € 309 235,20 Dirección TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Reino Unido Ver en el mapa Región East of England East Anglia Cambridgeshire CC Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Renata Schaeffer (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos