Objective
Tendons are part of the mechanosensitive musculoskeletal system and link muscles to bones. They have a predominantly mechanical role by regulating and transmitting forces. Tendon injuries are characterised by degraded tissue matrix that leads to inflammation and pain, and could lead to ruptures. The restoration process of tendons is extremely slow and although existing treatments include physiotherapy, the efficiency of loading has not been proven yet. This is due to our limited knowledge in how biophysical stimuli affects tendon healing, remodelling and biomechanical properties.
In this application, we propose to investigate how the response of tendons to loading can be used to accelerate Achilles tendon healing and enhance the tissue’s biomechanical properties. Our approach will combine computational and experimental models to investigate: 1) the multistructural biomechanical behaviour of the intact Achilles tendon; 2) explore the mechanobiological effects on tissue composition, structure and biomechanical properties during repair; 3) identify the biophysical stimuli that promote tendon differentiation.
This research will primarily develop novel computational tools that determine magnitudes and timing of loading on tendons that accelerate recovery and prevent re-rupture. The outcomes will help clinicians to improve the efficiency of existing therapies and propose new ones for enhanced tendon repair. The proposed project contributes to basic science on tendon mechanobiology which has clinical applications that improve public health.
This application plans to expand the researcher’s multidisciplinary research skills by giving her a new set of skills in experimental tendon mechanobiology and biomechanics. She will also hone her existing computational skills in musculoskeletal research to strengthen her niche. The researcher will have the possibility to conduct training in leadership and pedagogy to increase her chances to secure a faculty position after the fellowshi
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- social sciences educational sciences pedagogy
- medical and health sciences clinical medicine physiotherapy
- natural sciences biological sciences biophysics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
22100 LUND
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.